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ANTIOXIDANT DEFENCE AND DISEASE ACTIVITY IN RHEUMATOID ARTHRITIS PATIENTS

Author(s): B.Premkumar, A.Maheswaran and A.Shamshad

ABSTRACT

Oxidative stress is implicated in pathogenesis of rheumatoid arthritis and vitamin D deficiency is associated with severity of rheumatoid arthritis (RA).With this background the levels of superoxide dismutase, catalase and glutathione reductase and thiobarbituric acid reactive substances and vitamin D levels were analyzed.Twenty healthy subjects, twenty four Rheumatoid arthritis patients on methotrexate (MTX) monotherapy and fourteen patients who had not taken any pharmacological treatment, were recruited in the study. The oxidative stress was found to be high in Rheumatoid arthritis patients both naïve and those on methotrexate therapy, when compared to healthy controls. Antioxidant defense was found to be less in naïve patients and the disease activity score was found to be worsened in both treatment naïve and Methotrexate treated patients. Nutritional enrichment or antioxidant supplementation along with conventional treatment could improve the functional status in naïve Rheumatoid arthritis patients, whereas increment of vitamin D levels could improve the therapeutic outcome for patients on monotherapy with methotrexate.

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