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DEVELOPMENT AND EVALUATION OF POLYHERBAL FORMULATION CONTAINING METHANOLIC EXTRACTS OF TRICHODESMA INDICUM, ALLIUM SATIVUM AND ACORUS CALAMUS

Author(s): Azhaguraman Chidambaram, Dr AjithaDas Aruna and Bhuvaneshwari K

ABSTRACT

A polyherbal ointment containing methanolic extracts of whole plant of Trichodesma indicum, rhizomes of Acorus calamus and Allium sativum were prepared at 5% and 10% concentrations and subjected physical and pharmacological evaluations. The dermal toxicity studies revealed that the ointments were non toxic to the skin. The wound healing potential of the ointments was good. The polyherbal ointment though showing lesser rate of contraction (96.93 ± 1.15) of the wound but healing of the wound was complete up to the final stage at 10% Polyherbal ointment. The antimicrobial activity shows that the zone of inhibition was more than that of the standard Neosporin (14.5 ± 0.5)when compared with the polyherbal formulation at 10 % (18.8 ± 0.3). The scientific validation of the polyherbal ointment has proved the folklore claim of using the paste of the leaves of T. indicum, rhizomes of A. calamus and A.sativum.

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