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EVALUATION OF ANTIPYRETIC AND ANTIDIARRHOEAL ACTIVITY OF VARIOUS LEAF EXTRACTS OF BIXA ORELLANA LINN

Author(s): Subhashree Padhi and Sangram. K .Panda

ABSTRACT

Bixa orellana is an important medicinal plant of the family (Bixaceae) and it is highly valued from time immemorial because of its vast medicinal properties. The present work deals with the investigation of antipyretic and  antidiarrhoeal activity of various extracts of Bixa orellana leaves. Antipyretic  and  antidiarrhoeal activity was screened in using Wister strain albino rats and mice. All the crude extracts such as ethanol, ethyl acetate, methanol and petroleum ether were tested for antipyretic activity at 100 and 200mg/kg & antidiarrhoeal activity at 200 and 400  mg/kg by using Paracetamol (100 mg/kg) & loperamide (3 mg/kg) ) as standard drugs respectively.The extract was found to produce significant antipyretic & antidiarrhoeal activity in dose dependant  manner. The ethanol & ethyl acetate extract in a dose of 200 mg/Kg body weight exhibited significant antipyretic activity after 90 minutes and 120 minutes as compared to standard drug. Whereas the ethanol & methanol extracts were found to be effective  against castor oil induced diarrhoea on experimental mice  at the dose of 400 mg/kg body weight.

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