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SCREENING OF MUPIROCIN RESISTANCE IN METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS AMONG HEALTH CARE WORKERS AND DETECTION OF MUPA GENE BY PCR

Author(s): Dr. S. Mercy, Dr. K.R. Rajesh and D. Jegadeeshkumar

ABSTRACT

Increasing incidence of antibiotic resistance proves to be a major problem for health care industry. In particular methicillin-resistant Staphylococcus aureus (MRSA) seems to be increasingly a rapid emergence in nosocomial infections and colonization of the MRSA have resulted in development of further resistant to Mupirocin, antibiotic used in treatment of MRSA infections. This study investigated the occurrence of mupirocin resistance among 100 MRSA isolates from health care workers (HCWs) of Vinayaka Mission’s Kirupananada Variyar (VMKV) Medical College and Hospital identified the prevalence of MuL and MuH resistance among the MRSA and isolated the mupA gene  responsible for mupirocin resistant in MRSA. Investigation demonstrated that high incidence (63%) of MRSA isolation from an increased (79.9%) incidence of nasal carriage in HCWs. Prevalence of MuH resistance among MRSA isolates was significantly high in health care workers (75%), The study suggests periodical screening of HCWs for nasal carriage need to be carried out, and further steps to prevent transmission.

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